The Yukon Flats Center provides opportunities for higher education to residents of nine Interior Alaskan communities which lie along the Yukon River and its tributaries.  Only two communities, Circle and Central, are connected to the Alaska Highway system.  The other seven communities are accessible by airplane and/or boat.   The population of the region is approximately 1,320 people.  Approximately 86% are Alaska Native, predominantly Athabascan.

The Yukon Flats Center serves its students through a combination of distance delivery and local face-to-face courses.  Students have the opportunity to pursue several Certificate and Associate degrees and may also obtain a Bachelor's of Arts in some disciplines.  The Yukon Flats Center is currently a partner with the Council of Athabascan Tribal Governments offering various certificate and associate programs.