The Bristol Bay Campus serves 32 rural communities in the Bristol Bay region within a 55,000-square-mile area. The campus includes 12 coastal communities served by the Aleutian-Pribilof outreach center in Unalaska/Dutch Harbor: the Aleutian archipelago, lower Alaska Peninsula, the Shumigan Islands,and the Pribilof Islands. The campus' administrative center is in Dillingham (about 322 air miles from Anchorage and 570 air miles from Fairbanks), with centers in King Salmon, Togiak and New Stuyahok. Enrollment at Bristol Bay Campus ranges from 500 to 800 students each semester. The campus offers an Associate of Arts degree in general studies and Associate of Applied Science degrees in allied health, applied business, applied accounting, community health, early childhood education, human services, information technology, interdisciplinary studies and renewable resources. Bachelor's degree programs include elementary education, interdisciplinary studies, rural development and social work. Master's degrees are offered in rural development and education. Other programs include Adult Basic Education, providing adult basic education through high school-level instruction for Bristol Bay adults, and the Marine Advisory Program.

The Bristol Bay Campus also provides educational opportunities for communities in its service area, including vocational-technical, community interest and graduate courses. Classes are offered by distance delivery (audio conference, video conference, correspondence or Internet) and by instructors using traditional methods.

The Chukchi Campus is located 26 miles north of the Arctic Circle on the shores of the Chukchi Sea. The campus serves Kotzebue and 10 villages in a region of more than 36,000 square miles. Chukchi offers Associate of Arts as well as Associate of Applied Science degrees, and courses leading to baccalaureate degrees in education, rural development and social work. Courses are offered by local instructors and through the College of Rural and Community Development audio-conferencing and live Internet instructional systems.

The Interior Alaska Campus in Fairbanks serves 46 communities and villages in the Doyon and Tanana Chiefs regions throughout the interior of Alaska, an area about the size of France. The Interior Alaska Campus is the most decentralized of the UAF campuses. Although the director’s office and some faculty are located in Fairbanks, there are Interior Alaska Campus staff in Anchorage, Fort Yukon, Kenai Peninsula and Tok. Courses are offered online and by audio conference, on site by local or visiting instructors, and via intensive sessions in Fairbanks and Anchorage. The campus offers a range of degree programs, including occupational endorsements, certificates, and Associate of Arts and Associate of Applied Science degrees. Math and English tutors are available for all students taking courses through the campus.

The Kuskokwim Campus is located in Bethel and serves approximately 25,000 people in the Yukon-Kuskokwim Delta, which includes 47 remote Alaska Native Yup’ik and Cup’ik Eskimo and Athabaskan villages with 56 tribes in a 57,000-square-mile-area the size of Illinois. Bethel is a community of about 6,000 people 80 miles inland on the Kuskokwim River. KuC also operates one remote learning center based in Hooper Bay, a Yup’ik Eskimo community of 1,000 on the Bering Sea coast. KuC offers academic, vocational and community interest courses, as well as courses leading to associate, baccalaureate and master’s degrees, including a Bachelor of Arts degree in Yup’ik language and culture, the home language of many families in the region. The Emerging Scholars Program assists all full-time freshmen in the transition to college, both academically and socially, and in the completion of certificates and degrees. Students may attend classes on campus and through distance delivery. Housing on campus is available in Sackett Hall, which provides suites with space for four students in each.

Northwest Campus is located in Nome, a community of 3,500 that is the service hub for the 15 villages of the Bering Strait region. This 44,000-square-mile region extends from Shishmaref on the northern edge of the Seward Peninsula to Stebbins on the southern rim of Norton Sound. It includes communities on St. Lawrence and Little Diomede islands. The area contains 570 miles of coastline, which includes all of Norton Sound and portions of the Bering and Chukchi seas.

The Northwest Campus serves a total population of nearly 10,000. Certificates and associate, bachelor’s and master’s degrees are offered to the region’s residents, with courses taught both traditionally and by distance delivery. The campus responds to vocational, business development, cultural preservation and academic needs of the Bering Strait region. Many courses, programs and degrees are offered in cooperation with regional health and tribal organizations, school districts and corporations. Northwest Campus offers the high latitude range management certificate program supporting reindeer herding and husbandry.