All mammals depend on heat producing mechanisms to maintain body temperature. Skeletal muscle shivering and brown adipose tissue (BAT) uncoupling through the expression of uncoupling protein 1 (UCP-1) are the identified major sources of heat production, though recently, skeletal muscle has also been highlighted as a thermogenic source. Skeletal muscle nonshivering heat production occurs via sarcolipin (SLN) uncoupling of sarcoendoplasmic reticulum (SR) calcium ATPase (SERCA)-mediated ATP hydrolysis. My lab focuses on mechanisms of thermogenesis in a systems physiology approach to determine not only how mammals produce heat but also how multiple tissues communicate to regulate homeostatic temperatures. As humans also express SLN, the physiological mechanisms of these events provide insight toward a better understanding of metabolism within the context of temperature regulation and could expand our current understanding of thermoregulation in hibernating mammals, and eventually translate into future therapeutic developments for novel clinical treatments of obesity.
1. Kilarski, W., E. Güç, J. C. M. Teo, S. R. Oliver, A. Lund and M. A. Swartz. Intravital immunofluorescence for visualization of the microcirculatory and immune microenvironment in the mouse ear dermis. PLoS ONE 2013. 8(2): e57135.
2. Oliver, S. R., N.A Phillips, V.L. Novosad, M.P. Bakos, E.E.Talbert, and T.L. Clanton. Hyperthermia induces injury to the intestinal mucosa in the mouse: evidence for an oxidative stress mechanism. Am J Physiol Regul Integr Comp Physiol. 2012.
3. Oliver, S. R., V. P. Wright, N. Parinandi, and T. L. Clanton. Thermal tolerance of contractile function in oxidative skeletal muscle: no protection by antioxidants but reduced tolerance with eicosanoid enzyme inhibition. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2008. Nov; 295(5): R1695-705.
B.S. 2005, Shawnee State University
Ph.D. 2009, The Ohio State University
S. Ryan Oliver
Department of Chemistry & Biochemistry
900 Yukon Dr.
University of Alaska Fairbanks
Fairbanks, AK 99775