Marvin K. Schulte
Using a combination of Medicinal Chemistry, Protein Chemistry and Molecular Modeling my laboratory has been active in elucidating the molecular basis of ligand gated ion channel function. We are focusing on the allosteric regulation of these proteins and the use of allosteric regulators in treating diseases of the CNS. We are particularly interested in the development of treatments for cognitive disorders including Alzheimer's disease. While we have focused on ion channels in the past, projects are rapidly expanding into other areas relevant to cognition. Due to the complexity of these disorders, our research is highly collaborative. We are currently collaborating or consulting with colleagues at the University of Alaska Fairbanks as well as investigators in Hungary, West Virginia, Philadelphia and Montana.
Students and post-doctoral fellows in my laboratory receive research training in electrophysiology, receptor binding, plasmon resonance, molecular biology, protein chemistry and cell culture. Potential graduate students and interested undergraduate and High School students are encouraged to contact me for research opportunities.
1. Weltzin, A.A. and Schulte MK (2010) "Pharmacological characerization of the allosteric modulator desformylflustrabromine and its interaction with a4b2 nAChR Orthosteric ligands. JPET, (ebub).
2. Hazai E, Joshi P, Skoviak EC, Suryanarayanana A, Schulte MK and Bikadi Z. (2009) "A comprehensive study on the 5-hydroxytryptamine(3A) receptor binding of agonists serotonin and m-chlorophenylbiguanide". Bioorg Med Chem, 17(16), 5796-5805.
3. Ji, H.F., Gao, H., Buchapudi, K.R., Yang, X., Xu X. and Schulte M.K. (2008) “Microcantilever biosensors based on conformational change of proteins.” Analyst, 133(4), 434-443.
4. Hongyan G., Buchapudi, K.R. Smyth, A., Schulte, M.K. and Ji, H-F. (2008) “An Improved Surface Modification Approach for Micromechanical Biosensors” Lanmuir, 24 (2), 345-349.
5. Kim J.S., Pandya A., Weltzin, M., Edmonds, B.W., Schulte, M.K. and Glennon R.A. (2007) “Synthesis of desformylflustrabromine and its re-evaluation as an alpha4/beta2 nACh receptor modulator.” Bioorganic and Med Chem Letters.17(17):4855-60 .
6. Schulte, M.K., Hill, R.A., Bikadi, Z., Maksay G., Parihar, H.S., Joshi, P. and Suryanarayanan, A. (2006) “The Structural Basis of Ligand Interactions in the 5-HT3R.” Biological and Biophysical Aspects of Ligand-Gated Ion Channel Receptor Superfamilies., Ed. Hugo Arias. Research Signpost, 127-154.
7. Joshi, P.R., Suryanarayanan, A., Hazai, E., Schulte, M.K., Maksay, G and Bikadi Z. (2006) “Interactions of granisetron with an agonist-free 5-HT3A receptor model.” Biochemistry45(4):1099-105.
8. Suryanarayanan, A., Joshi, P. R., Bikadi, Z., Mani, M., Kulkarni, T. R., Gaines, C., and Schulte, M. K. (2005) "The loop C region of the murine 5-HT3A receptor contributes to the differential actions of 5-hydroxytryptamine and m-chlorophenylbiguanide." Biochemistry44(25), 9140-9149.
Research in Dr. Schulte's laboratory has been supported through grants from the National Science Foundation, The American Heart Association, the National Center for Research Resources (NCRR) (5P20RR016466) and the National Institute of Neurological Disorders and Stroke (NINDS) (R01NS057366 and R01NS066059). NCRR and NINDS are components of the U.S. National Institutes of Health (NIH). The content of published research is solely the responsibility of the authors and do not necessarily represent the official views of NCRR or NIH.
- B.S. 1982, St. John's University
- Ph.D. 1992, The University of Minnesota
Marvin K. Schulte
Department of Chemistry & Biochemistry
University of Alaska Fairbanks
Fairbanks, AK 99775-6160