Cheryl A. Frye

Research Description
Research in the Frye lab focuses on determining how steroid hormones work in the brain and influence behavior.  The primary research focus is on non-traditional or "non-genomic" actions of steroid hormones (termed neurosteroids) and their role in mediating reproductive behavior in rodents.   As diverse actions of steroids' mechanisms are revealed through reproductive behavior experiments, the role of different actions of steroids on developmental processes (puberty, pregnancy, aging, etc) and in mediating behaviorally-relevant processes (anxiety, learning, neuroprotection, etc) throughout the lifespan are examined.  This research program addresses basic mechanisms of steroid action and considers them in their full translational and clinical relevance using bench research, animal models, and collaborative clinical research.
Selected Publications
  1. Frye CA. (2009). Steroids, reproductive endocrine function, and affect: A review. Minerva Ginecol. 61, 541-62.
  2. Frye CA. (2009). Steroids, reproductive endocrine function, and cognition: A review. Minerva Ginecol. 61, 563-85.
  3. Frye C.A. (2009). Neurosteroids' effects and mechanisms for social, cognitive, emotional, and physical functions. Psychoneuroendocrinology 34 Suppl 1, S143-61.
  4. Frye, C.A. (2011) Novel substrates for, and sources of, progestogens for reproduction. Journal of Neuroendocrinology. 11: 961-73.
  5. Frye, C.A., Paris, J.J., Osbome, D.M, Joannalee, C.C., Kippin, T.E. (2011). Prenatal stress alters progestogens to mediate susceptibility to sex-typical, stress-sensitive disorders, such as drug abuse: a review. Frontiers in Psychiatry. 2: 1-15.
  • A.B. 1988, Wheaton College (Biopsychology)
  • Ph.D. 1992, Tufts University (Behavioral Neuroscience)
  • 1993-1995 NIH Post-doctoral Fellow, Neuroendocrinology, Boston University, Department of Biology
  • Eli Lilly Research Award for Post-Doctoral Research 1993-1995
  • Career Award NSF 1995-2003
  • North East Under/graduate Research Organization for Neuroscience, Founder 1996-present

phone: 907.474.5492
Cheryl A. Frye
Alaska INBRE
Box 757040
West Ridge Research Building, Rm 246
University of Alaska Fairbanks
Fairbanks, AK 99775-7000

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