Chemistry 451

Lecture #8: Protein Function: Hemoglobin and Antibodies

Read: pg. 161-186

Optional Reading:

Pg. 186-192 (antibodies)

Leninger Biochem in 3-D; Oxygen binding proteins (find link on chem 451 web page)

HW: (Due Wednesday, at end of class): Pg. 194 (5,7)

Optional HW: pg. 194 (1,2; Study exercises, 1,2,3,4)

Quiz #1 on Wednesday

Group Meetings after quiz: Bring Paper(s) and make a final selection for presentation

Objectives:

  1. Understand structure and function of hemoglobin and myoglobin
  2. Describe cooperative binding in terms of binding affinity and conformational change.
  3. Explain allosterism.
  4. Explain mechanism of muscle contraction.