Lecture #34: Nucleotide Metabolism

Read: pg. 694-704; 712-719 AND

HW: pg. 720 (Study Exercises 3,6,8; problem 5)

1. Know how PRPP levels influence purine and pyrimidine nucleotide synthesis.
2. Distinguish between de novo synthesis from salvage pathway. Note metabolic defects of Lesch-Nyhan syndrome.
3. Recognize de novo synthetic pathways for synthesis of UMP; contrast carbamoyl phosphate synthase II (pyrimidine synthesis) with carbamoyl phosphate synthase I (urea cycle).
4. Describe the metabolic defects, orotic aciduria, SCID and gout.
5. Know what compounds are produced by degradation of purines and pyrimidines.
6. Be thankful that #5 was the last objective you need to learn for biochemistry, fall 2000!! It has been fun!