Chemistry 451

Lecture #24: Electron Transport and Oxidative Phosphorylation

Read: Chapter on ECT and Oxidative Phosphorylation (pg. 493-527)

Optional Viewing: Guided Exploration 15: Electron Transport and Oxidative Phosphorylation Overview AND Guided Exploration 16: The Q Cycle

Optional Listening: The Chemiosmotic Theory

HW (due Monday, 11/13/00): pg. 527 (problems 1, 4, 5, 6, 7, 8, 9, 10)

Optional HW: pg. 527 (study exercises 4,7,8)

No Class on Friday 11/10/00

Objectives:
  1. Describe the anatomy (http://cellbio.utmb.edu/cellbio/mitoch1.htm#Menu) and evolutionary origin of mitochondria (http://dekalb.dc.peachnet.edu/~pgore/students/w96/joshbond/symb.htm)
  2. Know the role of the electron transport chain (ETC) in metabolism (How are electrons transported and how is a proton gradient established?) (i.e., the ETC transfers electrons in a series of redox reactions that produces a separation of charge across the inner mitochondrial membrane. Ultimately the ETC transfers electrons to O2 which is then reduced to H2O .(http://wwwclass.unl.edu/bios201/chapter5WEB/tsld005.htm;
  3. Know the role of the proton gradient in ATP synthesis.
  4. Know where specific ETC inhibitors act (Fig. 17-7) and the effects of these inhibitors on O2 consumption. (Why is O2 consumption a measure of ETC function)?
  6. Know the structure and function of ATP synthase .(http://plantcell.lu.se/LTM/06/3ATP.html;
  7. http://arc-gen1.life.uiuc.edu/Bioph354/lect10.html
  8. Describe the pleomorphism of mitochondria in adaptation to metabolic demand and seasonal change. (Bigger is better vs. membrane efficiency)?
  9. Be aware of the relationship between mitochondrial dysfunction, disease and aging. http://biochemgen.ucsd.edu/mmdc/ep-3-10.pdf ; http://www.pnas.org/cgi/reprint/91/23/10771.pdf