Chemistry 451

Lecture #11: Biological Membranes and Membrane Proteins

Read: pg. 233-241; 246 (peripheral membrane proteins) - 264

AND Azzam et al., 2000; Membrane changes during hibernation. Nature, 407, 317-318.

Optional Reading:

Animal Cell Organelles

Cytoplasmic membrane systems

Ion channels are integral membrane proteins

HW (Due Monday, Oct 9):

1. pg 238 (8,9,10); 277 (Problems; 3)

AND a OR b below:

a. pg 277 (Study Exercises; 1,3,4,7)

b. Discuss potential mechanism(s) and function of membrane changes during hibernation (Azzam et al., 2000)

Optional HW: pg 237 (4,5)

Objectives:

1. Know general structure of cholesterol and that cholesterol is a major component of animal plasma membranes.

2. Know that cholesterol is the precursor for steroid hormones, that cholesterol decreases membrane fluidity and accumulation of cholesterol in blood vessel cells leads to atherosclerosis.

3. Know the difference between integral and peripheral membrane proteins.

4. Understand the fluid mosaic model of biological membranes and how integral proteins and lipids diffuse laterally in the plane of the bilayer.

5. Know how the cytoskeleton can influence membrane protein distribution.

6. Understand the role of lipoproteins in the transport (delivery and disposal) of lipids in the body.