Instructor:

Dr. Kelly Drew

Office/office hrs:

184 NSCI / MWF 10:30-11:30

Telephone:

474- 5501

e-mail:

ffkld@uaf.edu

fax:

474-5640

Lecture:

MWF 9:15-10:15

NSCI 202

NSF 241

Homework:

Due at the end of class. Late HW is not accepted.

Course Description:

Prerequisite: Two semesters of organic chemistry (CHEM 321/322); First semester physical chemistry (CHEM 331) is recommended.

Text:

Other good reference Texts:

Order Direct through Amazon.com if possible; or see Sheila and she will order it for you.

Homework, Exams and Grading:

Unless otherwise indicated homework is due at the end of the next class after it was assigned. Late homework will not be accepted unless arrangements are made before the homework is late. Students may drop their 3 lowest homework grades. If you forget to hand in your homework at the end of class count it as one of 3 dropped grades; it will not be accepted for credit. Calculations must be included with answers (show your work) on HW, quizzes and tests or no credit will be given for the problem. There will be no make-up exams or quizzes except under extreme circumstances. If such circumstances arise notify Sheila (x5510) or I (x5501) before the scheduled time of the exam. If a make-up exam is approved it must be completed within 1 week of the original exam. Any student suspected by the instructor of cheating on a quiz or exam may be assigned a course grade of F; course drop forms will not be signed in these cases. The letter grades assigned will be based on the overall performance of the class but will usually be in the range 93-100=A, 80-92=B, 70-79=C, 60-69=D, and below 60 is failing.

2 Exams (100 pts ea.)

100 pts

3 Quizzes (25 pts ea.)

75 pts

Book Test

50 pts

Thinking Like a Biochemist

100 pts

Final Project (optional)

100 pts

Comprehensive final exam

100 pts

Homework (3 pts ea.)

Approx. 100 pts (3 lowest will be dropped)

Approximate Total Possible:

575 or 675 depending on if you choose optional final project

Date

Lecture #

Topic

Assignments/Reading in addition to HW

Sept

8

F

1

Snooze? You lose

Discuss group projects and potential topics related to molecular biology and protein structure and function. Pre-test take home

11

M

2

The Molecular Revolution: Nucleotides and Nucleic Acids

DNA Hyperchem Assignment, Due Friday 9/15

13

W

3

Nucleic Acid Sequencing and Recombinant DNA technology

15

F

4

Recombinant DNA continued...

Hyperchem Assignment Due

18

M

5

Amino Acids

Brain storm: Hand-in 3 ideas for topics for your first group presentation. Groups will be organized based on topics of interest.

20

W

6

Proteins, 1o structure and purification

Horton et al., 1998

22

F

7

Protein 2o, 3o and 4o structure

25

M

8

Protein Function: Hemoglobin and Antibodies

27

W

Quiz 1 and group projects

Group meeting/select paper. Title,time line and copy of paper due by 5:00 pm

29

F

9

Carbohydrates

Notification of slide or poster presentation

Oct

2

M

10

Lipids

4

W

11

Biological Membranes and Membrane Proteins

6

F

12

Group Presentations (1)

Poster reviews due by 9:15 a.m. on Monday

9

M

13

Transport across membranes

11

W

14

Enzyme: Nomenclature, Activation Energy, Serine Proteases

13

F

15

Enzyme Kinetics: Michaelis-Menton

16

M

16

Enzyme Kinetics: Inhibition and Regulation

18

W

Exam I (lectures 1-16)

Group meeting/select paper. Title, time line and copy of paper due by 5:00 pm

20

F

17

Intro to Metabolism: Overview and Review of Cells

Notification of slide or poster presentation

23

M

18

High E compounds and Redox Reactions

25

W

19

Glycolysis: Overview and Reactions

27

F

20

Group Presentations (2) ALS and Riluzole Ethnic Differences in Fatty Acids New Genes Found in Downs Syndrome Critical Region Microglia

Poster reviews due by 9:15 a.m. on Monday

30

M

21

Control of Glycolysis and The Pentose Phosphate Pathway

Nov

1

W

22

Glycogen Metabolism

3

F

23

Citric Acid Cycle

6

M

Quiz 2

Group meeting/select paper

8

W

24

Electron Transport and Oxidative Phosphorylation

Title, time line and copy of paper due at end of class

10

F

No Class! See Sheila (474-5510) to see if you were selected for slide or poster presentation

Notification of slide or poster presentation

13

M

25

Gluconeogenesis

15

W

26

Lipid Metabolism: Digestion, Fatty Acid Oxidation and Ketone Bodies

17

F

27

Group Presentations (3)

Poster reviews due by 9:15 a.m. on Monday

20

M

28

Fatty Acid Biosynthesis, Regulation of Fatty Acid Metabolism,

22

W

29

Exam II

24

F

Thanksgiving Break: Read book for book test

27

M

30

Book test

Group meeting/select paper

29

W

31

Amino Acid Catabolism and the Urea Cycle

Title, time line and copy of paper due at end of class

Dec

1

F

32

Metabolism: Organ specialization

Notification of slide or poster presentation

4

M

33

Mechanisms of Hormone Action: Signal Transduction

6

W

34

Nucleotide Metabolism

8

F

35

No Class!

11

M

36

Group Presentations (4)

Poster reviews due by 9:15 a.m. on Wed

13

W

37

Quiz 3

15

F

38

Questions/Answers

Dec

18

Comprehensive Final Exam