Potential PresentationTopics:

Potential PresentationTopics:

Gnosis (UA Library Catalog) [via telnet] . Click on Gnosis to see if we have the journal at UAF. Or, click on OCLC, find the abstract and it will tell you if we have it.

Papers in popular periodicals like Time, News Week, Scientific American and review articles will provide information on the topic and lead you to an original research paper. Look for a specific reference or an author's name that you can search for on PubMed.

Articles in BOLD are original research reports. Other articles are supportive news stories and reviews.

Metabolism

Andrews MT, Squire TL, Bowen CM, Rollins MB.Low-temperature carbon utilization is regulated by novel gene activity in the heart of a hibernating mammal. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8392-7. Full Text available on-line

Hellinga HW, Evans PR. Mutations in the active site of Escherichia coli phosphofructokinase. Nature 1987 Jun 4-10;327(6121):437-9

Zhao Z, Pascalar RW, Malencik DA, Anderson SR. Rabbit liver phosphofructokinase: rapid purification and phosphorylation site identification. Biochem Biophys Res Commun. 1996 May 15;222(2):410-5.

Oxidative Stress

Pandolfi PP, Sonati F, Rivi R, Mason P, Grosveld F, Luzzatto L. Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress. EMBO J. 1995 Nov 1;14(21):5209-15.

Leutner S, Czech C, Schindowski K, Touchet N, Eckert A, Muller WE. Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations. Neurosci Lett. 2000 Oct 6;292(2):87-90.

Nunomura A, Perry G, Pappolla MA, Wade R, Hirai K, Chiba S, Smith MA. RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. J Neurosci. 1999 Mar 15;19(6):1959-64. Article available on-line. Download PDF format.

Signal Transduction

Mouillet-Richard S, Ermonval M, Chebassier C, Laplanche JL, Lehmann S, Launay JM, Kellermann O. Signal transduction through prion protein. Science. 2000 Sep 15;289(5486):1925-8. (full text on-line).

Alzheimers Disease

Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Lieberburg I, Motter R, Nguyen M, Soriano F, Vasquez N, Weiss K, Welch B, Seubert P, Schenk D, Yednock T. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med. 2000 Aug;6(8):916-9.
Alzheimer's, Newsweek, 1/31/00

Helmuth L. Alzheimer's congress. Further progress on a beta-amyloid vaccine. Science. 2000 Jul 21;289(5478):375. (news report)

Ribosome structure and function: The original enzyme (Challenging)!

Cech TF. Structural biology. The ribosome is a ribozyme. Science. 2000 Aug 11;289(5481):878-9. (news report)

Nissen P, Hansen J, Ban N, Moore PB, Steitz TA. The structural basis of ribosome activity in peptide bond synthesis. Science. 2000 Aug 11;289(5481):920-30.

Ban N, Nissen P, Hansen J, Moore PB, Steitz TA. The complete atomic structure of the large ribosomal subunit at 2.4 A resolution. Science. 2000 Aug 11;289(5481):905-20.

Huntington' disease: Defeating polyglutamine repeats

Kazemi-Esfarjani P, Benzer S. Genetic suppression of polyglutamine toxicity in Drosophila. Science. 2000 Mar 10;287(5459):1837-40.

Martindale D, Hackam A, Wieczorek A, Ellerby L, Wellington C, McCutcheon K, Singaraja R, Kazemi-Esfarjani P, Devon R, Kim SU, Bredesen DE, Tufaro F, Hayden MR. Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates.Nat Genet. 1998 Feb;18(2):150-4.

Neurogenesis: New neurons for old brains; detecting replication of DNA

Eriksson PS, Perfilieva E, Bjork-Eriksson T, Alborn AM, Nordborg C, Peterson DA, Gage FH. Neurogenesis in the adult human hippocampus. Nat Med. 1998 Nov;4(11):1313-7.

Gould E, Beylin A, Tanapat P, Reeves A, Shors TJ. Learning enhances adult neurogenesis in the hippocampal formation. Nat Neurosci. 1999 Mar;2(3):260-5.

Transposons: Some DNA Can Jump

Davies DR, Goryshin IY, Reznikoff WS, Rayment I. Three-dimensional structure of the Tn5 synaptic complex transposition intermediate. Science. 2000 Jul 7;289(5476):77-85.

Protein Structure and Function (alpha-2-Mac and serine protease inhibitors)

Sottrup-Jensen L. Alpha-macroglobulins: structure, shape, and mechanism of proteinase complex formation. J Biol Chem. 1989 Jul 15;264(20):11539-42. Review.

Jenner L, Husted L, Thirup S, Sottrup-Jensen L, Nyborg J. Crystal structure of the receptor-binding domain of alpha 2-macroglobulin. Structure. 1998 May 15;6(5):595-604.

Ashcroft GS, Lei K, Jin W, Longenecker G, Kulkarni AB, Greenwell-Wild T, Hale-Donze H, McGrady G, Song XY, Wahl SM. Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing. Nat Med. 2000 Oct;6(10):1147-1153.

DNA Microarrays

Beuzen ND, Stear MJ, Chang KC. Molecular markers and their use in animal breeding. Vet J. 2000 Jul;160(1):42-52.

Burgess JK, Hazelton RH. New developments in the analysis of gene expression. Redox Rep. 2000;5(2-3):63-73. (LOOKS REALLY GOOD; Will need to order using interlibrary loan).

Lipids:

Stampfer MJ, Hu FB, Manson JE, Rimm EB, Willett WC. Primary prevention of coronary heart disease in women through diet and lifestyle. N Engl J Med. 2000 Jul 6;343(1):16-22.

Young TK, Gerrard JM, O'Neil JD. Plasma phospholipid fatty acids in the central Canadian arctic: biocultural explanations for ethnic differences. Am J Phys Anthropol. 1999 May;109(1):9-18.

Innis SM, Kuhnlein HV.The fatty acid composition of Northern-Canadian marine and terrestrial mammals. Acta Med Scand. 1987;222(2):105-9.

Hoppner K, McLaughlan JM, Shah BG, Thompson JN, Beare-Rogers J, Ellestad-Sayed J, Schaefer O. Nutrient levels of some foods of Eskimos from Artic Bay, N. W.T., Canada. J Am Diet Assoc. 1978 Sep;73(3):257-60.

Irving, L. Schmidt-Nielsen, K, Abrahamson, N. 1957. On the melting points of animal fats in cold climate. Physiol Zool 30:93-107. (Shows that the melting points of marrow fats declines as sampled from central to distal bones, but apparently this occurs fairly generally in mammals and is not necessarily unique in cold climates. Also see, Meng, M., West, G. C., Irving L. 1969. Fatty acid composition of caribou bone marrow. Comp Biochem Physiol 30:187-191

Membrane transport:

MacDonald JA, Storey KB Regulation of ground squirrel Na+K+-ATPase activity by reversible phosphorylation during hibernation. Biochem Biophys Res Commun. 1999 Jan 19;254(2):424-9.

Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA. A family of mammalian Na+-dependent L-ascorbic acid transporters. Nature. 1999 May 6;399(6731):70-5.

Your choice, however, instructor approval is required