Chemistry 104

Lecture #19: Nucleic Acids, building blocks and DNA replication

Read: pg. 631-643 AND Biochemistry Poster Assignment

HW: pg. 662-664 (2a,e,5a,8-13,20,35,37,39,50)

Test Corrections AND 3 ideas for a poster topic are due one week from today

Objectives:

  1. Consider the future of Medicine (cloning [clones are not the perfect replicas we thought; What doctors think; Why we should ban human cloning; The human genome project; 5 cloned piglets; cloned monkey], genetic engineering [Designer Seeds], genetic screening, DNA fingerprinting, designer babies)! (Get serious) (DNA animations)
  2. Know that genes are strands of DNA carried on chromosomes (with protein thrown in for regulation of gene expression).
  3. DNA nucleotides consist of: 1) a nitrogen base (purine or pyrimidine), 2) a sugar (deoxyribose) and 3) a phosphate (attached to the sugar as a phosphate ester).
  4. Know that DNA is a polymer of nucleotides. When nucleotides are linked via a phosphate sugar backbone they are called nucleic acids.
  5. Be able to draw the phosphate sugar backbone of DNA.
  6. Know that purines and pyrimidines spell the genetic code (only 4 letters): A=adenine, T=thymine, C=cytosine, G=guanine.
  7. Know that A pairs with T (via 2 hydrogen bonds) and C pairs with G (via 3 hydrogen bonds).
  8. Pairing of a long purine with a short pyrimidine produces rungs of equal length on the DNA ladder (double helix).
  9. Illustrate how a double stand of DNA can unzip and serve as a template for an identical double strand of DNA (DNA replication).