The Tanana District is one of the largest Cooperative Extension districts geographically in the United States, covering an area over 120,000 square miles with a current population of approximately 100,000 distributed in 64 Native villages and the Fairbanks North Star Borough. Much of the district is inaccessible by road.

The Tanana District clientele is very diverse including 4-H leaders, youth groups, homeowners, homemaker clubs, private and commercial agriculture, local government, military personnel, subsistence families, cooperating agencies, and the general public.