Genetics of Obesity in Yupiit

Bert Boyer visits a friend over a cup of tea.
Photo by James Barker

Obesity is one of the most common preventable causes of morbidity and mortality, and ethnic minorities are often disproportionately affected. There is considerable evidence that a combination of genetic and environmental factors lead to the development of obesity.

In particular, diet and physical activity are important modulators, yet we know little about the molecular mechanisms of how gene-by-environment interactions trigger body fat accumulation.

The overall objective of this research study is to identify the contribution of selected candidate genes, dietary factors, and physical activity, to the development of obesity in Yup’ik people in Southwest Alaska.

Bert Boyer, Ph.D., Principal Investigator
NIH/National Institute of Diabetes and Digestive and Kidney Diseases/Center for Inherited Disease Research, R01DK074842

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